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MedPharm’s Formulation Strategy

Pre-formulation studies are tailored to each delivery route and formulation type to understand:

Drug solubility

Drug stability

Compatibility with excipients and manufacturing solvents or reagents

Controlled-Release Approaches

MedPharm develops a range of localized and depot-based delivery systems, including:

Thermosensitive and thixotropic gels
Dissolution-controlled gels
Polymer tortuosity and binding systems
Slow-degrading matrix polymers
Encapsulation systems such as PLGA microparticles
In-situ depot formulations

Formulation Development Considerations

Depending on the delivery route and formulation type, MedPharm evaluates:

Drug substance characteristics
Drug in solution versus suspension
Solubilizers, co-solvents, and suspension stabilizers
Encapsulation efficiency
Permeation enhancer selection
pH and microbial preservation
In-situ formulation metamorphosis driven by pH, temperature, or hardness
Device compatibility

Delivery to Unconventional Epithelium

Please connect with a scientist to learn more about MedPharm’s custom model development, including integrated device and biological systems.

IVPT Using Micro Vertical Diffusion Cells

Penetration and permeation assessment
Animal or human cadaver tissue
Surgical resections
Optional synthetic mucous layer

Reconstructed Mucosal and Epithelial Models

Includes: Vaginal and cervical epithelium, gastrointestinal epithelium

Penetration and permeation assessment
Reconstructed from human cells
Maintains tissue integrity with tight junctions
Mucous production
Irritation measurements
Mucoadhesion assessment
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